The Fix
Clock time,is not body time.
Many drugs vary in effect and safety by time of day. Practice rarely accounts for each patient’s circadian context. Deepdose turns that gap into actionable timing.
Standardised dosing hides heterogeneity
Trials and guidelines often fix one clock time for everyone, diluting benefits that show up when dosing matches internal rhythm and daily routines.
Key mechanisms are rhythmic
Glucose tolerance, insulin sensitivity, blood pressure, and hormone systems — including the renin–angiotensin–aldosterone system (RAAS) and cortisol — shift across 24 hours, changing how drugs work.
Highest-risk groups get missed
Non-dippers, nocturnal hypertension, shift workers, sleep apnea, and dawn phenomenon often gain most from tailored timing — yet are rarely flagged in primary care.
Barriers block adoption
Short visits, adherence worries, and no simple tools push GPs towards one-size instructions instead of individualised chronotherapy.
Why fixing it helps
- Matched timing can lower night-time blood pressure, blunt morning glucose peaks, and improve side-effect profiles — especially in high cardiovascular risk.
- Individual timing respects sleep, meals, and work — improving efficacy without fighting adherence.
What clinicians need
- Quick phenotyping: dipper vs non-dipper, sleep timing, shift work, dawn-risk — without full ambulatory testing.
- Evidence-graded rules: per-drug timing impact (high / medium / low) with references and confidence.
- Electronic health record (EHR) support: proposed times, interaction flags, patient preferences recorded.
- Trial-ready modules: pragmatic single-patient (n-of-1) or clinic pilots to build local evidence fast.